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KMID : 0370220040480020111
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Yakhak Hoeji
2004 Volume.48 No. 2 p.111 ~ p.116
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Antioxidative Activity and Protection of Oxidative Chromosomal Damage by Vegetables, Fruits Extract and Their Functional Liquid Formulation
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이승철/Lee SC
허찬/이승현/김현표/허문영/Heo C/Lee SH/Kim HP/Heo MY
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Abstract
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The ethanol extracts of mixed vegetables (Bioactive Vegetables, BV), mixed fruits (Bioactive Fruits, BF) and their liquid formulation (Chungpae Plus(R), CP) were ev aluated for their antioxidatlve and antigenotoxic activities. They were shown to possess the significant free radical scavenging effect against 1,1-diphenyl-2- picryl hydrazine (DPPH) radical generation and were revealed to show the inhibitory effect of lipid peroxidation as measured by malondialdehyde (MDA) formation although the potencies were not higher than those of vitamin C. They did not possess any pro- oxidant effect on bleomycin-Fe(III) dependent DNA degradation, whereas vitamin C showed strong prooxidant effect. Furthermore, oral administration of BV and BF inhibited micronucleated reticulocyte (MNRET) formation of mouse peripheral blood induced by KBrO3 treatment in vivo. CP also showed significant inhibition under same experimental condition. Therefore, the liquid formulation (CP) containing BV and BF may be a useful natural antioxidative and antigenotoxic agent by scavenging free radicals, inhibition of lipid peroxidation and protecting chromosomal damage.
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KEYWORD
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